Collagen degradation
نویسندگان
چکیده
منابع مشابه
Degradation of newly synthesized collagen.
Explants of rabbit lung parenchyma maintained in serumfree medium incorporate I 14Clproline and I Wllysine into collagen as I “Clhydroxyproline and I Wlhydroxylysine at a constant rate for at least 24 h. Evaluation of the size distribution of the [14Clhydroxyproline and [‘4Clhydroxylysine containing peptides within the explants demonstrated that 20 to 40% of the LY chains of newly synthesized c...
متن کاملMacrophage-mediated degradation of crosslinked collagen scaffolds.
Biological scaffolds used in tissue engineering are incorporated in vivo by a process of cellular in-growth, followed by host-mediated degradation and replacement of these scaffolds, in which phagocytic cells from the monocyte/macrophage cell lineage play a key role. The chemical degradation of scaffolds with collagenases is well established, but to date this has not been correlated with an in ...
متن کاملType-specific collagen degradation by eosinophils.
Despite the association of eosinophils with wound-healing and fibrotic processes, their collagenolytic ability has been poorly defined. By using highly purified eosinophil preparations (greater than 95% eosinophils) obtained from guinea-pigs by peritoneal lavage, we have examined type-specific collagen degradation by eosinophils using sensitive detection methods. The results show that eosinophi...
متن کاملCollagen degradation in ischaemic rat hearts.
Myocardial extracellular matrix is organized into a complex arrangement of intercellular and pericellular fibres and fibrils that serves as a supporting framework for contracting cells. Recent evidence suggests that changes in ventricular shape and function occurring after ischaemic injury may be related to alterations of this matrix. In this report we describe the rapid and extensive loss of c...
متن کاملMatrix metalloproteinase dependent and independent collagen degradation.
Cleavage of the fibrillar collagens occurs during physiological conditions, as well as pathological conditions. The resistance of the fibrillar collagens to degradation is due to their rigid and compact structures. There are only a limited number of proteinases that have the capability to initiate the cleavage of the fibrillar collagens. These include some of the matrix metalloproteinases (MMPs...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2012
ISSN: 1934-1792
DOI: 10.3180/react_150401.1